Alcoholic hepatitis has high short-term mortality with limited medical therapeutic options. Liver transplantation remains controversial for this indication given inability of these patients to meet six months of sobriety. Despite emerging data on early liver transplant as salvage therapy for severe alcoholic hepatitis, barriers remain on the acceptance of this option in the routine clinical care of these patients.
Alexandre Louvet, MD, PhD
Alexandre Louvet is professor of hepatology in the gastroenterology department of the University Hospital of Lille, France, headed by Prof. Philippe Mathurin. He earned his medical degree from the University of Lille. He received his PhD degree after a fellowship in the Institut Mondor de Recherche Biomédicale in Créteil, France, where he worked on the role of the endocannabinoid system in alcoholic liver disease in mice. His clinical interests include alcoholic liver disease, non-alcoholic fatty liver disease, hepatocellular carcinoma and viral hepatitis.
He is involved in both clinical and basic research. His main topic in research is alcoholic hepatitis (natural history, treatment, disease modeling, transplantation, and pathophysiology). He has published several papers on the management of patients with severe alcoholic hepatitis. He is a member of the governing board of the French Association for the Study of the Liver (AFEF), of the editorial board of the Journal of Hepatology and a reviewer for several journals specialized in hepatology.
Ashwani K. Singal, MD, MS, FACG, FAASLD
Dr. Singal is an Associate Professor of Medicine at the University of South Dakota Sanford School of Medicine and Transplant Hepatologist at the Avera Transplant Institute. In addition, he also directs the hepatology elective course for the senior medical students at the Sanford Medical School and is Chief of Clinical Research Affairs at the Avera Transplant Institute. With clinical and translational research interests in alcoholic and non-alcoholic fatty liver diseases, renal injury in cirrhosis, and porphyria, Dr. Singal’s research has been funded by the American College of Gastroenterology, National Institute of Health, and pharmaceutical industry.
He has over 160 original peer reviewed articles in national and international journals and book chapters. As an active executive member of the ACG practice parameters committee, Dr. Singal has developed practice guidelines for alcoholic liver disease and vascular disorders of the liver and currently involved in writing the guidelines on nutritional management of patients with cirrhosis. He also reviews research grants and scientific research abstracts for the AGA and AASLD. Dr. Singal is currently the Secretary and the Education subcommittee Chair of the Alcoholic Liver Disease Special Interest Group at AASLD.
Thomas D. Schiano, MD, FAASLD
Dr. Thomas D. Schiano has a clinical background in hepatology, gastroenterology and clinical nutrition. He has expertise in the management of persons with cirrhosis and other acute/chronic liver diseases, and in caring for patients prior to and after liver transplantation. Dr. Schiano has varied clinical research interests including alcohol-related liver disease, nutritional aspects of liver disease, recurrence of disease post-liver transplantation, living donor liver transplantation, and management of the complications of cirrhosis. In addition, he is involved in the care of patients pre- and post-intestinal transplant. He is a member of the liver thrombosis program, an international referral center for adults and children with difficult to diagnose and unique blood clotting disorders affecting the liver and the intestines.
Dr. Schiano is a UNOS-certified Liver Transplant physician, and is board certified in clinical nutrition, gastroenterology and transplant hepatology. Dr. Schiano completed fellowships in Hepatology and Liver Transplantation at The Mount Sinai Hospital, Gastroenterology at Temple University Hospital, and Clinical Nutrition at Memorial Sloan-Kettering Cancer Center. He completed a residency and chief residency in internal medicine at Maimonides Medical Center.
Dr. Schiano is Professor of Medicine, Medical Director of Adult Liver Transplantation and Director of Clinical Hepatology at the Recanati/Miller Transplantation Institute. He is also Medical Director of the Intestinal Transplant program.